Abstract: A low grade copper-nikel ore in sichuan contains Cu 0.18%，Ni 0.43%.Gangue minerals mostly is magnesium silicate，for example，talc and serpentine.Based on process mineralogy characteristics of this special low grade ore，adopting the closed circuit flowsheet by no removing talc in advance one roughing，two cleaning and four stages of scavenging for bulk flotation of Cu and Ni,one roughing，one cleaning and three scavenging for separating Cu and Ni returning of middling in turn，and a new special depressant WL-001 was added.Then，copper concentrate with Cu and Ni grade of 20.11% and 0.67% at a 55.86% Cu recovery，nickel concentrate with Ni and Cu grade of 5.57% and 0.60% at a 73.96% Ni recovery were respectively achieved by laboratory test.

Key words: Copper-nickel ore, Depressant, Copper-nickel bulk flotation, Copper-nickel separation