Abstract: A refractory Cu-Zn plans to be developed by selective followed flotation technology from Guangxi.As part of the zinc and copper minerals floatability similar, in order to obtain a better test indicators, combined using small molecule organic inhibitors Yn and collector Z-200 to carry out the closed-circuit test, obtained the copper concentrate with copper 23.15% and recovery rate of 78.24%, zinc grade 5.61%, comparing to inhibitors ZnSO₄+Na₂SO₃, copper grade and copper recovery were increased by 4.59 percentage points and 8.83 percentage points, lower 2.61 percentage points of zinc of copper concentrate.

Key words: Refractory Cu-Zn ore, Small molecule organic inhibitor Yn, Inhibiting zinc floating copper