Abstract: According to mineral characteristics of low grade,high oxidation rate and close intergrowth of a refractory lead-zinc ore.The process flowsheet of part lead selective flotation and lead-zinc bluk flotation was adopted.Test results indicate that under the conditions of appropriate grinding and reagent system, a lead concentrate contenting Pb 58.71%with recovery 21.81%and contenting silver 7 476.81 g/t with recovery 14.39%，and a lead zinc mixed concentrate contenting Pb 25.61%，Zn 23.64%，Ag 5 593.42 g/t with the corresponding recovery 54.39%,65.67%,59.49% can be obtained.The total recovery of lead is 76.20%, the total recovery of zinc is 67.24% and the total recovery of associate silver is 73.88%.

Key words: Refractory lead-zinc ore, Part selective flotation, Bulk flotation, Comprehensive recovery