Abstract: A lead-zinc mine in Guangxi belongs to refractory mine with low lead of 0.88% and high zinc of 9.19% in fine dissemination. The main Zn-containing mineral is sphalerite,and Pb-containing minerals are complex,including jamesonite,boulangerite and galena in very fine dissemination. In order to realize the high efficient exploitation and utilization of the resources,beneficiation tests of lead and zinc separation of the ore were made. Results showed that under the grinding fineness of 80% -0.074 mm,zinc concentrate with Zn grade of 48.05% and zinc recovery of 91.13%， and lead-antimony concentrate with lead grade of 26.63%， antimony grade of 21.80%， lead recovery rate of 87.46% and antimony recovery of 86.30% were obtained respectively by the process of lead concentration by one roughing，two scavenging and three cleaning，zinc concentration by one roughing，two scavenging and three cleaning，mixture of one cleaning of lead-zinc tailing and one scavenging of lead-zinc concentrate back to regrinding，and the rest middlings back to the flow-sheet in turn. The reason for low content of lead in lead-antimony concentrate is that the main lead-containing minerals，jamesonite and boulangerite，contain low lead content in theory with fine disseminated particle，which are not suitable for fine grinding and deep concentration.

Key words: Lead-zinc ore, Sphalerite,Jamesonite, Lead and zinc separation, Middlings back to regrinding