Abstract: The copper-nickel sulfide ore in Xinjiang with uneven distribution of minerals，wide range particle size distribution，and complex embedment，is a low grade natural copper and nickel sulfide ore associated with gold.Beneficiation experiments of Cu-Ni bulk flotation and then separation of Cu and Ni process are conducted in order to high efficiently recover copper and sulfur.Results indicated that，at the grinding fineness of 70% passing 0.074 mm，copper concentrate with copper grade of 22.36% and recovery of 65.33%，gold grade of 115.00 g/t and recovery of 63.94%，nickel concentrate with nickel grade of 6.11% and recovery of 71.25% were obtained through the process of Cu-Ni bulk flotation of one roughing-three cleaning-one scavenging，Cu and Ni separation of one roughing-two cleaning-one scavenging，and middles back to the flow-sheet in turn to deal with the ore.

Key words: Copper-nickel sulfide ore, Copper-nickel bulk flotation, Separation of copper and nickel