Abstract: The reagent is the key for the recovery of fine cassiterite by flotation. A large number of research and production practices have shown that the combination of reagents can promote the comprehensive recovery of cassiterite. In order to systematically and comprehensively understand the research and application of reagent of fine cassiterite， the use status of combined collectors， combined regulators， collectors and regulator for fine cassiterite flotation are reviewed， The advantages， mechanism and application status of combined reagents are introduced， and it is pointed out that achieving a better production target by using combined reagent is inseparable to the synergy between the reagents.

Key words: Fine cassiterite, Combined reagents, Combined regulators, Synergy