Abstract: Luobuzhen Pb-Zn polymetallic deposit in western South Gandese metallogenic belt is located in Angren County in Tibet.Based on the analysis of the regional metallogenic geological background and the geological characteristics of deposits，combined with the latest exploration results of the mining area，analysis of the ore-controlling factors， geochemical characteristics of the ore-hosting rocks and deposit genesis are conducted.The study results show that:①the mineralization bodies are mainly hosted in contact position between Paleocene-Eocene of Linzizong Group Pana Formation of dacite and biotite plagioclase granite porphyry，monzonitic granite porphyry，the orebodies are obviously controlled by NWW fracture，and also controlled by strata and magmatic rock，the orebodies are distributed with elenticular and stratoid forms，and obvious zoning characteristics，the mineralization alteration is very strong，and silicide，chloritization，carbonate lithification and pyritization are the main alteration in mineralization types；②ore-bearing biotite plagioclase granite porphyry and dacite are formed in Eocene and it is the product under the same magmatic activity；③biotite plagioclase granite porphyry and biotite have similar geochemical characteristics，which indicated that they have the same initial magma origin， biotite plagioclase granite porphyry with the geochemical characteristics of Ⅰ type granite，the petrogenetic type biotite plagioclase granite porphyry is the same as the ore-hosting rock of porphyry copper deposit in China；④Luobuzhen Pb-Zn polymetallic deposit belongs to the magmatic hydrothermal with mantle-derived properties，the ore-forming materials have multi-source characteristics and its metallogenic age is less than 51 Ma.Based on the above discussion results，the relative prospecting prediction study is done.The results show that the potential area B，where the Ⅱ# and Ⅲ# mineralized belts are located has good metallogenic prospect in north of Luobugangmu area，it is worth conducting further prospecting and exploration work in the area.

Key words: Pb-Zn polymetallic deposit, Deep prospecting, Geological characteristics, Ore-controlling factor, Deposit genesis, Prospecting indicator, Prospecting prediction