Abstract: The property change of the sulfide ore of Tonglushan Copper-Iron Mine led to the decline in copper recovery. Laboratory test was made on using MB and MOS-2 collector combination instead of sodium isobutyl xanthate. The following industrial test indicated the MB and MOS-2 collector combination can raise the copper, gold and silver recoveries of copper concentrate by 0.49，3.62 and 3.47 percentage points respectively, and meanwhile, reduce the No. 2 oil consumption by more than 40%. In this way, the adoption of this collector combination for the sulfide ore of this mine can bring an economic benefit of 1.6506 million yuan per annum.

Key words: Sulfide ore, Copper separation, MB and MOS-2 collector combination, Isobutyl xanthate, Recovery