Abstract: In order to provide a basis for rational development and utilization of a Bi-Zn-Fe polymetallic ore，and in view of the nature of the ore，using SN-9^# as selective collector of bismuth minerals，beneficiation experiments is made by the process of bismuth-zinc successive flotation-low intensity magnetic separation.With the addition of combined depressant Na₂SO₃ + ZnSO₄ in coarse concentration，and new environment-friendly efficient inhibitors CK-1^# and CK-2^# in clean flotation of bismuth and zinc respectively，bismuth concentrate with Bi grade of 17.96% and Bi recovery of 68.08%，zinc concentrate with Zn grade of 48.03% and Zn recovery of 88.61%，and iron concentrate with Fe grade of 66.11% and Fe recovery of 66.15% are obtained separately，which effectively realizes the comprehensive recovery of bismuth，zinc and iron.In addition，silver 823.57 g/t and indium 301 g/t are also enriched from bismuth concentrate and zinc concentrate.

Key words: Bismuth-zinc-iron polymetallic ore, Bismuth-zinc successive flotation, Low intensity magnetic separation, Depressant CK-1^#, Depressant CK-2^#