Abstract: The major research advances of lead-zinc sulfide flotation separation technology are summarized.The characteristics，application scope，advantages and disadvantages of various lead-zinc sulfide flotation technologies are analyzed.The theoretical study progress of lead-zinc sulfide flotation separation from flotation electrochemistry，simulation of molecular mechanics and quantum chemistry are summarized.Moreover，major advances on collectors of lead-zinc sulfide ore，organic and inorganic depressant in the lead-zinc sulfide flotation separation，and zinc sulfide ore activator are also reviewed.On this basis，the research emphasis and research direction of technique of lead-zinc sulfide ore separation is prospected.

Key words: Lead-zinc sulfide ore, Flotation technology, Flotation theory, Flotation reagent