Abstract: According to the characteristics of the low grade copper-nickel ore in Xinjiang，adopt a closed circuit test flowsheet which have one roughing，two scavenging and two concentrating copper-nickel mixed floating；and one roughing，one scavenging copper-nickel separation，middlings order returned.Reagents used in copper-nickel mixed flotation are the combined depressants of CMC and Sodium silicate，collecter iso-butyle Xanthate and assistant collecter A8. Copper-nickel separation medicament is conducted: using Activated Carbon to remove reagents，lime and T12 as the Inhibitors，Z-200 for collector.The Copper concentrate is obtained with Copper grade of 27.03%，nickel grade of 0.93% and Copper recovery of 67.79%. the mixed concentrate of copper and nickel is obtained with nickel grade of 5.59%，copper grade of 3.79% and nickel recovery of 70.82%，copper recovery of 29.14%.

Key words: Copper-nickel ore, Mixed flotation, Copper-nickel separation, A8, T12