Abstract: With the mixed concentrates of fluorite and barite comprehensively recovered from a lead-zinc tailing in Hunan province as the research object，the type and dosage of inhibitors and collectors were selected by inhibiting barite and floating fluorite，and the close circuit conditional tests were made. The results showed that with the YZ-4 as the efficient inhibitor of barite and sodium oleate as the efficient collector of fluorite，fluorite concentrate with CaF ₂ grade of 96.81%，and the recovery of 92.44%，and barite concentrate with BaSO₄ grade of 91.36%，the recovery of 86.75% and the density of 4.25 g/cm³ were obtained respectively by the process of one roughing-four cleaning-one scavenging and middle concentrates back to the flow-sheet in turn. By this means，the efficient separation of fluorite and barite was realized.

Key words: Fluorite, Barite, Separation, Inhibitor, Collector