Abstract: It is a world-wide technical challenge for mining of steeply inclined large and thick ore body when surfaces are not allowed to collapse.For such kind of ore body，the mining methods often used at home and abroad are high stage open stoping with subsequent filling and high sublevel open stoping with subsequent filling.Taking large and thick ore body in Lilou iron ore as an engineering example，the mining method is primarily selected from open stoping method，caving method，filling method according to the morphology of the orebody and stability of ore rock.From the production capacity，mining engineering layout，mining preparation engineering，technology，stope filling cycle，25 m high sublevel open stoping with subsequent filling method and the high stage lateral caving stoping with subsequent filling method are analyzed and compared.Finally，the high stage lateral caving stoping with subsequent filling method is proposed as main mining method associated with 25 m high sublevel upwards fan-shaped open stoping with subsequent filling method and the shrinkage stoping with short hole，which realized safe，efficient and large-scale production.With the development of drilling equipment，charging equipment，blasting equipment，the large hole blasting and high sublevel or drilling are more and more widely applied in the mine，which provides a certain reference for mines with similar mining conditions.

Key words: Steeply inclined large and thick ore body, Mining method, Open stoping with subsequent filling method