Abstract: A low-grade copper-nickel ore in Guangxi contains Cu of 0.25% and Ni of 0.43%.Nickel mainly exists in the form of pentlandite，while copper in the form of chalcopyrite.Both copper and nickel minerals have a certain degree of oxidation and are closely disseminated.In order to provide a basis for the development and utilization of the ore，beneficiation experiments were carried out.By process comparison of copper flotation and then nickel，copper-nickel bulk flotation，bulk flotation of copper-nickel and then separation，magnetic separation-copper-nickel bulk flotation，the copper-nickel bulk flotation process was chosen to deal with the ore.The research by the process indicated that copper-nickel mixed concentrate with copper grade and recovery of 5.77% and 86.33%，nickel grade and recovery of 8.31% and 76.60% respectively were obtained at the grinding fineness of 74% passing 0.074mm，with sodium carbonate as regulator，butyl xanthate as collector，2# oil as frother，through the process flowsheet of one roughing，two-cleaning，and two-scavenging.

Key words: Low-grade copper-nickel ore, Pentlandite,Chalcopyrite, Copper-nickel bulk flotation