Abstract: A medium-scale copper-sulfide mineral resource was found by deep resources exploration in a large-scale Lead-zinc Mine. In order to exploit them efficiently，beneficiation tests are carried out by adopting the process of copper-sulfide bulk flotation and copper-sulfide separating flotation based on its mineral properties and probe experiments. The results showed that with the grinding fineness of 75% passing 0.074 mm，lime as pH regulator，butyl xanthate as collector，2# oil as frother，mixed concentrate was achieved through one roughing，two-scavenging bulk flotation operation. Copper concentrate with copper grade of 14.22%，recovery of 87.58%，and sulfur concentrate with sulfur grade of 34.01%，recovery of 80.84% was obtained respectively through one roughing，two cleaning，two scavenging of copper flotation and sulfur depression process at the grinding fineness of 80% -0.038 mm，with lime as pH regulator，LP-01 as collector. Thus copper and sulfur resources were comprehensively recovered.

Key words: Copper-sulfide ore, Copper and sulfide bulk flotation, Copper and sulfide separating flotation, Regrinding