Abstract: Cuttings geochemical survey method as an initial exploration method is widely used in geological prospecting work.Due to the large distribution scope of secondary halo anomalies，how to narrow the scope of target zone，reduce the interference to mineralization anomalies and lower the workload anomalies verification to locate the ore-body accurately become the important problems that should be solved in the process of geochemical exploration work.Based on the 1∶10 000 cuttings geochemical survey data of Mazhala mining area in Comai county，Tibet，five types of element association Au-Sb-As，Pb，Hg，Zn，Ag，are divided by adopting the factor analysis method and cluster analysis method.Besides that，the factor score isopleth map is drawn so as to discuss the Au prospecting direction and narrow the target prediction area.Based on the actual geological situation of the mining area，it is concluded that the materials source of the Au，Sb and As are different to the other elements obviously in the mining area.The southeastern and northwestern corners are the good area of metallogenic potential.Further exploration should be conducted the tectonic intersection location area in mining area，and some exploration verifications should be carried out in the southern and northwestern corner in the mining area.