Abstract: Based on analyzing the geological background of mineralization in the research area，the geological and geochemical characteristics of Quemocuo Pb-Zn deposit，which is located in northern section of Sanjiang metallogenic belt，Tuotuo river area，Qinghai province are discussed，the results show that：①the deposit of ore rock is mainly Permian Labuchari group carbonate，which is the advantageous source layer of lead-zinc mine and relatively enriched with the ore-forming elements such as Pb，Ag，Zn，As，Sb，Cd; ②the ore-body is obviously controlled by fracture structure with secondary fault structure closely related to mineralization，which is also accompanied with silicification，baratization and carbonatization; ③the ore-forming fluid has the characteristics of low temperature，low salinity，low density and so on，the geological characteristics of mining area and isotopic characteristics reflect the participation of magmatic hydrothermal activity in ore-forming fluid; ④until now，among eight Pb-Zn ore-bodies found，lead grade is 1.65%~7.17%，zinc grade is 1.13%~5.7% and Pb+Zn(334) metal capacity is 188 800 t，the metal ore deposit is in medium size，and the prospecting prospective of the deposit is good.Combining with the regional geological background，geological and geochemical characteristics of ore deposit，the source of ore-forming materials，ore-controlling factors，and metallogenic factors are discussed.The results show that the ore deposit belongs to the hypabyssal low temperature and hydrothermal type Pb-Zn deposits，besides that，the prospecting marks are summarized based on the characteristics of strata，tectonic，alteration，mineralization，geophysical and geochemical feature.The above research results can provide some reference for the prospecting work in the research area.

Key words: Geological characteristics, Geochemical characteristics, Deposit genesis, Prospecting marks