Abstract: A lead-zinc ore in Fujian belongs to a refractory lead-zinc sulfide ore with characteristics of complex mineral composition，complex dissemination and close associations with each other.In order to high efficiently exploit and utilize the resources，experimental study on the ore was made by adopting the preferential flotation process.Results showed that under the grinding fineness of 70％ -0.074 mm，lead concentrate with Pb grade of 41.46% and recovery of 81.76%，and zinc concentrate with Zn grade of 48.26% and recovery of 84.88% were obtained respectively by the process of lead concentration with one roughing-three cleaning-two scavenging，zinc concentration with one roughing-three cleaning-one scavenging，and middlings back to the flow-sheet in turn.The selective flotation process is a highly efficient method for exploiting the ore.

Key words: Lead-zinc sulfide ore, Selective flotation, Lead flotation and zinc suppression