Abstract: The genesis and prospecting direction of the iron polymetallic deposits located in the Yong'an-Meizhou depression belt are discussed by analyzing the ore-bearing stratum,sedimentary characteristics,ore-forming material sources and the superimposition and reworking process caused by the Yanshanian intermediate-acidic magmatism of the iron polymetallic deposits located in the Yong'an-Meizhou depression belt.The research results show that:①the lower Jingshe formation dominates major ore-bearing stratum of the iron polymetallic deposits,followed by the upper Qixia formation,iron is mainly derived from submarine volcanism;②Pb,Zn,W,Sn and other metal elements derive from both sedimentation and magmatism;③the iron polymetallic elements are remobilized，superimposed and enriched by the intermediate-acidic magmatism intrusions of Yanshanian，spatially forming the Fe-Mo and Fe-Pb-Zn polymetallic ore.Based on the above analysis results，it is considered that the ore-genesis of Makeng-type iron deposit is marine volcanic sedimentation-magmatic hydrothermal superimposition，the ore-prospecting should be oriented on both sides of ultra-crustal faults zone along Yushui-Makeng-Yangshan in the southeast Yong'an-Meizhou depression belt，therefore，it can provide some reference for the prospecting work in the research region.

Key words: Makeng-type iron deposit, Submarine volcanism, Metallogenic characteristics, Genesis of mineral deposit, Prospecting direction