Abstract: There is 0.19% copper and 0.42% nickel in a refractory copper-nickel sulfide ore from Jilin.Copper and nickel ore mineral paragenesis significantly，fine disseminated.To provide technique basis for the development and utilization of the ore，copper and nickel bulk flotation-copper and nickel separation flotation process was conducted.The results show:at the grinding fineness of -0.074 mm accounted for 80%，using copper sulfate as activator，ethyl xanthenes + butyl ammonium aeroflot as collector，2# oil as the foaming agent，CMC for selection inhibitors via one roughing-three cleaning-two scavenging for copper and nickel bulk flotation to achieve Cu-Ni bulk concentrate，reground the Cu-Ni bulk concentrate to -0.038 mm accounted for 90%，with lime as inhibitor，ethyl xanthate as collector endure one roughing-three cleaning-two scavenging copper and nickel separation flotation，copper concentrate with copper grade of 24.62%，copper recovery of 79.04%，nickel grade of 0.73%，nickel recovery of 1.06% of the，nickel concentrate with nickel grade of 5.73%，nickel recovery of 5.73%，copper grade of 0.11%，copper recovery of 3.22% was achieved.Comprehensive recovery of the copper and nickel was realized.

Key words: Copper-nickel sulphide ore, Bulk flotation, Flotation, Separation