Abstract: School of Minerals Processing and Bioengineering，Central South University，Changsha 410083,China There is 2.63% lead and 0.37% zinc in a lead sulfide ore from Xinjiang.Lead mainly occurs in galena，some of which in form of cerussite，sardinianite，and plumbojarosite.To provide technique basis for the development of the ore，beneficiation experiment was conducted.Results indicated that，using sodium sulfide + sodium carbonate + zinc sulfate as depressor (adding into the ball mill)，at the grinding fineness of 74% passing 0.074 mm，using 25# aerofloat and ethyl xanthate as collector，via one roughing-two cleaning-three scavenging closed circuit flotation process，lead concentrate obtained with lead grade of 63.66%，the recovery rate is 63.66%，zinc grade of 1.02%.The results can provide technique basis for the determination of ore beneficiation process.

Key words: Lead sulfide ore, Flotation, Lead flotation and zinc depression