Abstract: The grade of copper and lead is 0.54% and 2.12% in a low grade copper-lead sulfide ore from Yunnan.In order to determine the beneficiation process of copper and lead，mineral processing experiment was conducted via the principle process of copper and lead bulk flotation and then separation.The results showed that：when the grinding fineness reaches 75.40% -0.074 mm，copper concentrate with 25.32% copper，7.96% lead and copper recovery of 82.06%，and lead concentrate with 58.36% lead，0.73% copper，and lead recovery of 85.61% was obtained by one roughing，two cleaning，one scavenging copper and lead bulk flotation，and one roughing，three cleaning，two scavenging copper and lead separation process.

Key words: Copper-lead sulfide ore, Bulk flotation of copper and lead, Separation of copper and lead, Lead depression and copper flotation