Abstract: There is 0.61% Sb and 1.02% As in a high arsenic antimony ore from Guizhou.Antimony mainly occurs as stibnite，while arsenic occurs as arsenopyrite.To provide technique basis for the development of the ore，beneficiation experiment was conducted on the ore.Antimony depression and arsenic flotation process，arsenic and antimony bulk flotation and then separation process，antimony flotation and arsenic depression process comparison experiment results indicated that，antimony flotation and arsenic depression process index is relative well.At the grinding fineness of 0.074 mm passing 92.78%，by antimony preference flotation and arsenic depression process，using sodium silicate as depressor，lead nitrate as activator，diethyl dithiocarbamate and ammonium dibutyl dithiophosphate as collector，2# oil as frother，via one roughing and one cleaning antimony preference flotation，antimony concentrate with antimony grade of 57.49% and recovery of 79.52% was obtained，the content of arsenic decreased to 0.54%，antimony tailings via one roughing-two cleaning-two scavenging arsenic flotation，arsenic concentrate with arsenic grade of 10.17% and recovery of 82.79%，gold grade of 29.16 g/t and recovery of 80.98%，and 1.04% antimony was obtained，effective separation recovery of antimony and arsenic was realized.

Key words: Arsenic, Antimony, Flotation, Antimony preference flotation and arsenic depression