Abstract:  A mine is an old mine with complex hydrogeological conditions and many years of production. It is mined by open stope method. Many middle sections are produced at the same time. There are many stopes and low production efficiency. Sometimes there are problems such as stope caving，which seriously affect the safety production of the enterprise. In order to solve these problems，the enterprise adopts the sublevel open stope followed by filling mining method. Although the safety of stope mining is greatly improved，the mine adopts the multi sublevel production，which causes the interaction between the middle sections，low production efficiency and potential safety risks. In this paper，on the premise of sublevel open stope followed by filling mining method，and according to the Moore Coulomb failure，the numerical simulation software is used to make numerical simulation on different mining sequences of the stopes. The change of stress and displacement of stopes in different mining sequences is analyzed，so that the mining sequence suitable for the mine can be selected，which provides a basis for the mine to realize intensive and large-scale mining. It is of vital significance for the safe，efficient and economic mining of the mine，and also for the mining of similar mines. The reference basis is provided for the similar mines.

Key words: Sublevel open-stoping method, Subsequent filling, Mining method, Intensive mining, Optimization of mining sequence