Abstract: The paper analyzed the difficulties in separation of Manganese and Silver for a silver-bearing multi-metal manganese ore from the angle of process mineralogy. With a reference to the process mineralogy study of similar ores, and combining with the nature of this ore, one suitable process is proposed, which consists of dry screening classification-dry coarse high intensity magnetic separation-wet fine high intensity magnetic separation-mixed concentrate wet leaching.Through the laboratory tests, a mixed concentrate grading at 31.59% of manganese, 657.9g / t of silver, 11.72% of iron with a Mn recovery of 90.24%, Ag recovery of 91.29%, Fe recovery of 78.51% were achieved respectivelyThis process provides a basis for large scale, high-efficiency and low cost production of similar ores.