Abstract: A certain Cu-Pb-Zn poly-metallic sulfide ore in Xinjiang has a close associated relationship with each other and owns complicated ore nature.In view of its characteristics，the beneficiation tests with the process of copper-lead mixed flotation，mixed flotation separation for copper-lead concentrate and zinc concentration with mixed flotation of tailings are carried out.Then copper concentrate with Cu grade of 28.34% at an 85.26% recovery，lead concentrate with Pb grade of 53.18% at an 85.53% recovery，and zinc concentrate with Zn grade of 57.40% at an 85.71% recovery are obtained respectively.It provides a basis for reasonably recovering these mineral resources.

Key words: Copper-lead-zinc multi-metal sulphide ore, Copper-lead flotation, Copper-lead separation, Zinc flotation