Abstract: In view of characteristics of easily-floating and uneven distribution of valuable minerals for a poly-metallic Cu-Pb-Zn sulfide mine in Qinghai，the beneficiation tests were carried out by process of prior flotation of copper，lead and zinc in turn with new-type special collector YK1-11 and new-type inhibitor YK3-09. And the inverse flotation was adopted in lead concentration. Then，copper concentrate with Cu grade of 18.02% at a 57.50%recovery，lead concentrate with Pb grade of 51.43% at a 33.20% recovery，zinc concentrate with Zn grade of 45.83% at a 48.95% recovery，Pb-Zn concentrate mixture with Pb and Zn grade of 31.53% and 38.46% at a 42.56% Pb recovery and 34.05% Zn recovery were respectively achieved. Also，the associated silver in ores was effectively enriched，thus providing a basis for rational exploitation of the ores.

Key words: Poly-metallic Cu-Pb-Zn sulfide mine, Prior flotation, New-type collector YK1-11, New-type inhibitor YK3-09, Inverse flotation of copper