Abstract: In order to reduce the copper content of Nanjing Pb-Zn-Ag Ore lead concentrates and obtain qualified copper concentrate，adopted K₂Cr₂O₇+CMC as lead combined depressants，Jiangxi university of science and technology researched and developed the LP-01 as copper collector to the lead concentrates on copper flotation separation in laboratory. The copper content of lead concentrate reduced from 1.01% to 0.41%，and access to the copper concentrate with grade 18.12%，recovery 61.05%. Based on the test in laboratory further industrial experimental was done，the lead concentrates with copper content reduced from 2.85% to 1.34%，and received copper concentrate grade 21.68%，copper recovery 56.39%. Industrial experiment also shows that the wastewater of copper concentrate and final lead concentrate containing Cr⁶⁺ can be recycled by the sodium sulfite+lime，thus maximum limit avoids Cr⁶⁺ pollution to the environment.

Key words: Lead concentrate, Cu-Pb separation, Combined depressants K₂Cr₂O₇+CMC, Copper collector LP-01