Abstract: Experimental research on Chambishi mixed copper ore is carried out by the flow-sheet of copper oxide flotation and copper sulfide flotation in sequence. The results show that with grinding fineness of -0.074 mm 80%，and the THF + ammonium sulfate as the combined activator of copper oxide，copper concentrate with Cu grade of 25.89% and recovery of 83.44% was finally obtained by the process of one-roughing flotation for copper sulfide removal，one-roughing flotation for copper oxide removal，and three-cleaning for mixed ores，and middlings back to the flow-sheet in order.

Key words: Mixed copper ore, Combined activator, Sulfidizing flotation