Abstract: The structure and formation of a copper-lead-zinc polymetallic sulfide ore from Huludao county Liaoning Province with rich in gold and silver is complex，and it is difficult to separate copper，lead and zinc from each other. In order to high efficiently develop and utilize the ore，beneficiation experiments were conducted through process of bulk flotation of copper and lead-copper and lead separation for rough concentrate-zinc flotation and sulfur depression for rough tailings. The results showed that copper concentrate with copper，gold and silver grade of 20.88%，2.37 g/t and 1 808 g/t，copper，gold and silver recovery of 85.72%，46.27%，22.46%，lead concentrate with lead，gold and silver grade of 63.13%，0.99 g/t and 5 973 g/t，lead，gold and silver recovery of 80.00%，19.57%，75.16%，zinc concentrate with zinc，gold and silver grade of 55.96%，0.35 g/t and 37.80 g/t，zinc，gold and silver recovery of 84.21%,10.47%，0.72% were obtained respectively through process of two roughing-one scavenging-two cleaning for copper and lead bulk flotation，one roughing-two scavenging-three cleaning for separation of copper and lead，one roughing-two scavenging-two cleaning for lead flotation，middles back to the flow-sheet in turn. Copper，lead and zinc of the ore have been well separated and recovered.

Key words: Cu-Pb-Zn polymetallic sulfide ore, Bulk flotation of copper and lead, Separation of copper and lead, Sulfur depression and zinc flotation