Abstract: In order to strengthen the deformation prediction of high and steep slope in open-pit mine，and timely obtain the trend of the landslide，the landslide pre-warning was conducted，which guided the mine production and ensured the safety of people′s life and property.A combined prediction model was established，and the modeling ideas and calculating methods were introduced in the paper.On this basis，according to the actual monitoring data of a high and steep slope，the predicted results were analyzed and compared with the predictions of the independent model.The results showed that the precision of the combined model is superior to that of the independent model with higher reliability.Therefore，it owns strong applicability.

Key words: Combined prediction model, Grey model, Linear regression model, Neural network