Abstract: A lead-zinc mine in northwestern China is a large-scale refractory Pb-Zn deposit with characteristics of complex mineral composition，uneven lead-zinc mineral distribution，micro-grained and complex dissemination，difficulty in liberating monomer mineral and hard gangue mineral.In order to determine the utilization scheme about the Pb-Zn deposit，experimental study on the ore is made by adopting the preferential flotation process.The results indicate that under the conditions of grinding fineness of 85% -0.074 mm，lead concentrate with Pb grade of 60.45％，Zn grade of 8.90％ and lead recovery of 75.95％，and zinc concentrate with Zn grade of 51.60%，Pb grade of 0.31% and zinc recovery of 87.39% were obtained respectively with closed circuit process of lead concentration by one roughing，one scavenging and three cleaning (regrinding to 95% -0.045 mm before the cleaning)，zinc concentration by one roughing，one scavenging and two cleaning process，and middlings returning to the flow-sheet in order.The process is an efficient utilization scheme for this ore.

Key words: Lead-zinc mine, Galena, Sphalerite, Preferential flotation