Abstract: Whether Chalcopyrite can be effectively depressed or not is the key to realize the separation of copper-molybdenum，while Na2S and other traditional inhibitors mostly have problems of the large dosages，serious environmental pollution，damage to the health etc.In order to obtain high efficient inhibitors of less toxic and dosage，three kinds of new organic inhibitors are designed and synthesized with CAMD technology and compared with three conventional inhibitors in interaction with chalcopyrite for calculation of energy change respectively.Comparison tests for actual inhibitory effect are conducted，and the optimum pH value is determined when the inhibitor has best performance.The strength order of the interaction energy with chalcopyrite by MS software is BK511>BK509>BK516> sodium thioglycolate>Na2S>NaHS，which shows that BK511 has the best copper depression performance in copper-molybdenum separation.BK511 has better performance in alkaline environment for copper depression and molybdenum flotation.With BK511 total dosage of 7.4 kg/t，through the process of two roughing-one cleaning，regrinding(78% -0.038 mm) and five cleanings，middllings back to the flowsheet in turn，molybdenum concentrate with molybdenum grade and recovery of 46.31%，89.94%，and copper content of 1.04%，copper concentrate with copper grade of 22.69% and recovery of 99.97%，molybdenum content of 0.033% are obtained.Dosage of BK511 is obviously lower than that of Na2S，which greatly reduces the environmental pollution.

Key words: Chalcopyrite, Molybdenum, Copper and molybdenum separation, Inhibitor, CAMD technology