Abstract: A Cu-Ni mixed concentrate from Western Panzhihua contains 3.60% Cu，7.91% Ni.Copper and nickel mainly exist in form of sulfide minerals.Copper and nickel are micro-fine disseminated and closely associated with each other，thus difficult to be separated by flotation.In order to improve the flotation separation efficiency，experiments on copper flotation and nickel depression were carried out after being reground and reagent removal.The results indicated that：after grinding the ore (at grinding fineness of -0.026 mm passing 76%) with active carbon and sodium sulfide and removing the reagents，through the process of one roughing，three cleaning，two scavenging and middles back to the flow-sheet in turn，copper concentrate with 28.88% Cu，0.78% Ni and copper recovery of 84.55%，nickel concentrate with 8.75% Ni，0.62% Cu and nickel recovery of 98.96% were obtained respectively.In conclusion，good separation of Cu-Ni mixed concentrate was obtained.

Key words: Cu-Ni mixed concentrate, Reagent removal, Grinding, Copper flotation and nickel depression