Abstract: There is a sulfide-containing low grade bauxite ore in Guizhou Province，with Al₂O₃ content of 54.71%，SiO₂ content of 11.35%，alumina-silica ratio is only 4.82，and 1.33% S.Aluminum mainly exists in form of diaspore，and mainly sulfide-containing ore is pyrite.For fine dissemination of the valualde minerals，entrainment may occur when desulfurization，and is difficult to achieve good separation index.In order to high efficiently develop and utilize the resources，desulfurizing and desilication closed circuit flotation experiment was conducted.Results indicated that:at the grinding fineness of 90% passing 0.074 mm，through one roughing-three cleaning-one scavenging desulfuration flotation，tailings of scavenging endure two roughing-four cleaning-one scavenging desilication flotation，tailings of scavenging from desulfuration cleaning endure two roughing-one cleaning-one scavenging desilication flotation process cleal with the ore，sulfide concentrate with 33.72% S，15.96% Al₂O₃，4.98% SiO₂，and sulfide recovery rate of 75.16%，and bauxite concentrate with 61.13% Al₂O₃，7.39% SiO₂，mass ratio of Al₂O₃ to SiO₂ is 8.27，aluminum recovery rate of 79.64% was obtained.One time grinding，desulfurization and desilication flotation process is an effective process for dealing with the ore and can provide reference for the concentration of sulfide-containing bauxite ore.

Key words: Bauxite ore, Flotation, Desulfuration, Desilicication