Abstract: Application of the stope method with subsequent backfilling is a high-efficient mining method，and it has become the general trend of mining technology for large and extra-large underground mine.Combining with Mathews stability graph method and FLAC3D numerical simulation，the stope structural parameters are preliminarily determined by Mathews stability graph method，and the preliminary scheme is optimized by FLAC3D numerical simulation method to obtain the optimal stope structural parameters.Taking Zhangzhuang iron mine as an example，investigations on the stope mining with subsequent backfilling in stage of application，drilling，and ore withdrawal for large and thick ore-body are made to analyzed the stope stability under different structural parameters and different exposed area.The reliable mining stope parameters obtained can provide some foundation for the application and popularization of the open stope with subsequent backfilling.

Key words: Backfilling method, Mathews stability graph, Numerical analysis method, Parameters of stope structure