Abstract: With the feature of high oxidation，fine dissemination size and the easy-to-slime gangues，a refractory copper oxide ore in Tibet has copper grade of 1.76%，and copper oxidation rate 44.32%.According to the characteristic of the copper oxide ore，a technological process of flotation separation was adopted through the process of differential rough flotation and combined cleaning of sulphide copper ore and oxide copper ore.The results indicated that under grinding fineness of -0.074 mm for 85%，water glass as inhibitor and dispersant of slime，amyl xanthate as collector，sodium sulfide as vulcanizator of copper oxide minerals，ammonium sulfate as auxiliary activator，and pine oil as frothing agent，a copper concentrate with copper grade of 21.19% and copper recovery of 78.74% was obtained by the process of two-rouging，two-cleaning and two-scavenging.

Key words: Copper oxide ore, Sulfur-oxygen asynchronous flotation, Sulfurization, Activation, Suppression, Slime dispersion