Abstract: There is 3.60% lead and 9.19% zinc in a lead-zinc oxide ore from Sichuan．The oxide rate of lead and zinc is above 90%.It is fine-grained dissemination,being a refractory lead-zinc ore.Experimental study was conducted to provide technique basis for the exploitation and utilization of the ore．Results show that at the grinding fineness of 96.74% passing 325 mesh ,lead concentrate with lead grade of 48.61%,recovery of 86.15%,zinc concentrate with zinc grade of 40.14%,recovery of 65.04% was obtained by the process of one-roughing，three-cleaning，one-scavenging using Na2S as regulator,amyl-xanthate as lead collector to preferential floating lead,and lead flotation tailings via the process of one-roughing，three-cleaning,two-scavenging with Na2S as sulfurizing reagent,AgNO3 as activator，sodium silicate as dispersants and inhibitors for gangue minerals ,octadecylamine as collector to select zinc．

Key words: Lead-Zinc oxide ore, Flotation, Activator