Abstract: There is 2.10% Pb，3.805% Zn，and 35.85 g/t Ag in a lead-zinc polymetallic ore in Dajianshan of Guangdong.Lead and zinc mainly exists in form of sulfide minerals，lead sulfide and zinc sulfide accounts for 95.71% and 95.84% of total lead and total zinc，respectively.To provide technique basis for development and utilization of the ore，beneficiation experiment was conducted.Results indicated that，at grinding fineness of 80% passing 74 μm，using CaO as pulp pH regulator，zinc sulfide as depressor，ammonium dibutyl dithiophosphate + butyl xanthate as collector，via two roughing three cleaning four scavenging flotation，tailings of lead flotation using CaO as pulp pH regulator，CuSO₄ as activator，butyl xanthate as collector，via one roughing three cleaning four scavenging flotation，lead concentrate with 60.29% Pb，recovery of 92.02%，826.13 g/t silver，recovery of 72.75%，3.64% Zn，Zinc concentrate with 48.32% Zn，recovery of 92.30%，and 0.95% Pb was obtained.

Key words: Lead-zinc polymetallic ore, Priority flotation, Silver