Abstract: A refractory lead-zinc sulfide ores with low grade and fine-grained disseminated in Inner Mongolia contains 1.47% lead and 1.93% zinc. In order to determine the utilization process of the ores， flotation tests of lead and zinc was carried out on the basis of process mineralogy. The results showed that: ① Lead and zinc in the ores are mainly in the form of sulfide phase. The Main metallic minerals in the ores are marmatite and galena， and the contents of pyrrhotite and pyrite are high. Galena ，marmatite and other minerals are coexistent. Galena is disseminated with medium-particles ， mainly between 0.64 mm and 0.01 mm grain size， while marmatite is disseminated with fine-particles， mainly between 0.16 mm and 0.01 mm grain size.② In the case of grinding fineness of 80% -0.074 mm，lead concentrate was obtained through one roughing， four cleaning and three scavenging flotation. Zinc primary concentrate was selected by one roughing four scavenging from lead tailings. After regrinding zinc primary concentrate to 90% -0.025 mm， zinc concentrate was obtained through four cleaning. Lead concentrate with lead grade of 52.23%，zinc grade of 3.18%，lead recovery rate of 74.81% and zinc concentrate with zinc grade of 42.05%，lead grade of 1.98%，zinc recovery rate of 85.83% were finally obtained. The process effectively realized the separation and recovery of lead and zinc.

Key words: Lead-zinc sulfide ores, Galena, Marmatite, Process mineralogy, Flotation separation