Abstract: Bulk flotation was usually utilized to deal with polymetallic sulphide ore bearing Cu，Pb and Zn. Then the obtained mixed concentrate was subjected to separate Cu from Pb by flotation. The separation between Cu and Zn was considered as the crucial step for this process. With respect to a mixed concentrate obtained from Cu-Pb-Zn polymetallic ore by flotation， in this paper， experimental study on Cu-Pb flotation separation was carried out. The effects of reagent removal as well as main parameters of flotation were investigated. The experimental results indicated that favorable separation results were obtained by using activated carbon as reagent removal medium. The optimized dosage of activated carbon was 200 g/t and the stirring time for reagent removal was 10 min. By using combined depressant to float copper-bearing mineral while restraining lead-bearing mineral， the suitable dosage of depressant and stirring time were 800 g/t and 10 min， respectively. After that， lime of 400 g/t， zinc sulfate of 400 g/t， sodium sulfite of 300 g/t， butyl xanthate with ammonium butyrate black drug of （5+5） g/t， and the second oil of 10 g/t were added successively. Under the optimized test conditions， the copper concentrate with the copper grade of 24.15%， the copper recovery rate of 80.57% ， and the lead concentrate with the lead grade of 31.63% and the lead recovery rate of 65.35% could be obtained respectively. The separation effect of copper and lead was fine， which laid an important theoretical basis and technical support for the efficient utilization of the studied resource.

Key words: copper-lead mixed concentrate, flotation, separation of the copper and lead, reagent removal with actived carbon, combined inhabitors