Abstract: Multi-layer orebody as a kind of complex and difficult to mine orebody there are many outstanding problems in the traditional mining method.It is of great significance to carry out innovative mining method study to realize the safe，efficient and green mining of this kind of orebody.Based on the guidance of mining concepts such as "synergetic mining" and "non waste mining"，this paper fully absorbs the idea of “synergistic utilization of goaf”，and takes the safe and efficient mining of multi-layer orebody as the goal，puts forward a new method of multi-layer orebody waste separation synergetic mining，and designs the specific implementation ideas of two typical inclined multi-layer orebodies.In theory，the optimal cooperative thickness relationship of multi-layer horizontal gently inclined orebody is established，the calculation formula of the optimal synergistic height of the unexploded interlayer of multi-layer inclined steeply inclined orebody is derived，and the definition of the synergistic degree of separation of ore and waste is introduced to quantify the applicability of the new mining method.Based on the mining technical conditions of a multi-layer gently inclined orebody of a copper mine in Yunnan Province and a two-layer orebody of a phosphate mine in Guizhou Province，the new mining method proposed in this paper is analyzed in engineering cases.The study results show that the new mining method has significant advantages in reducing the transportation cost of waste rock，reducing the loss and dilution rate of ore and improving the mining efficiency compared with the traditional mining method under certain mining technical conditions.The new mining method proposed in this paper could help for solving the mining technical problems of multi-layer complex orebodies，besides that，it also has certain promotion and application value.

Key words: Synergetic mining, Multi-layer orebody, Separation of ore waste, Mining method