Abstract: In order to solve the problem of disorderly diffusion of flue gas in the Lingnan Gold Mine， a regional mine reversal technology was proposed，based on Ventsim software，three-dimensional equally-proportional ventilation network and mine anti-wind model were established，and mine air volume distribution and fire smoke CO distribution under taking anti-wind measures were calculated.The on-site anti-wind test was designed to verify the implementation effects of anti-wind technical scheme.The study results showed that:①The air inlet route of Lingnan Gold Mine -610 m 2# blind shaft wellhead cable short-circuit fire occurred，after taking the measures of -370 m return fan station fan reversing of east air shaft，stopping the 8# pulse through skip well -770 m return air lane fan and -690 m 10# pulse through lane fan，through Ventsim software calculation，the reverse air volume of the -370 m main return fan station was 63.3 m3/s， and the fan reverse wind efficiency 60.2%.Main inlet and return air area wind reverse，fire smoke CO was discharged along 1# shaft， and fire smoke flowed in the expected direction.②CO detection points were set in the stope near stone door at the bottom of 1# shaft and the main return fan station of -370 m east air shaft.After the fire happened， the peak value of CO in the main return fan station of -370 m east air shaft is 2 830.4×10-6 without anti-wind measures；after taking anti-wind measures， there was no CO on the operating surface of the fire outlet.At the bottom of 1# shaft， the CO concentration reached a peak of 2 914 ×10-6 at 2 500 s， and decreased to 18×10-6 at 7 500 s.After anti-wind measures were taken，CO was discharged along the shortest path.③Field reverse wind test results showed that the total positive return air volume of the -370 m fan in the middle section was 106.5 m3/s，it took 4 minutes for the fan to transition from positive to reverse.Ten minutes later， the back air volume was 74 m3/s， accounting for 69.48% of the normal ventilation volume，which met the requirements of related specifications，the ability of mine ventilation system to resist fire catastrophe was significantly improved.

Key words: mine ventilation, mine fire, regional anti-wind, multi-station ventilation system, simulated test