Abstract: The mineral composition of Cu-Sn polymetallic ore from Inner Mongolia is complex，with 1.05% copper and 0.47% tin，the main impurity components SiO2 was up to 62.31%.Chalcopyrite，the mainly copper mineral，mainly exists in quartz gangue minerals as irregular shape，the cassiterite exists mainly in hypidiomorphic-allotriomorphic structure，intergranular with chalcopyrite and other minerals.To provide technique basis for the utilization of the ore，separation experiment research was carried on.The results show that：copper rough concentrate can be obtained at the grinding fineness of 75% passing 0.074 mm，with Y150 as rough flotation collector，D300 as scavenging flotation collector，2# oil as foaming agent，through one roughing-two scavenging flotation process，rough concentrate with copper grade of 3.12%，recovery of 97.06% was obtained，rough concentrate via four cleaning，two scavenging process，copper concentrate with copper grade of 16.30%，copper recovery of 92.14% can be obtained，tailings of copper flotation via one stage gravity separation by shaking table，tin concentrate with tin grade of 8.67% and recovery of 74.91% was obtained.

Key words: Cu-Sn polymetallic sulfide ore, Chalcopyrite, Cassiterite, Flotation, Gravity separation