Abstract: There is 1.32% lead and 8.17% zinc in a lead-zinc sulfide ore from Yunnan.Lead mainly occurred in galena and zinc mainly occurred in blende.Metallic minerals is closely paragenesis and is difficult to separate lead from zinc.Laboratory experimental study was conducted to provide technique basis for the exploitation and utilization of the ore.Results show that at the grinding fineness of 0.074 mm passing 74.60%，lead concentrate with lead grade of 54.25%，recovery of 84.66% and zinc content of 2.92%，zinc concentrate with zinc grade of 48.32%，recovery of 90.19% and lead content of 0.10% was obtained by the processing of one-roughing，three-cleaning，one-scavenging using lime as regulator，sodium silicate as inhibitor for gangue，zinc sulphate + sulfite combination as inhibitors for zinc，diethyldithiocarbamate and butyl aerofloat as lead collector，pine camphor oil as foaming agent to preferential floating lead，and lead flotation tailings via the process of one-roughing，three-cleaning，one-scavenging with the copper sulfate as activator，butyl xanthate as collector，pine camphor oil as foaming agent to select zinc closed circuit flotation tests.

Key words: Lead-zinc sulfide ore, Combined collector, Preferential flotation