Abstract: Contents of lead and zinc in a lead-zinc sulfide ore containing antimony in Western Yunnan are 3.91% and 1.87% respectively，associated valuable elements are antimony and silver.To determine the suitable mineral process，beneficiation experiment was carried out.Results show that lead concentrate with lead grade and recovery rate 61.25% and 90.40% respectively，and containing antimony 6.40% and 39.32% silver，antimony recovery rate is 72.41%，and silver recovery rate is 75.62%，zinc concentrate with zinc grade and recovery rate are 46.57% and 81.06% respectively，was obtained via one roughing-four cleaning-two scavenging lead flotation，one roughing-three cleaning-one scavenging zinc flotation process.

Key words: Lead zinc ore, Flotation, Zinc depressing and lead flotation, Zinc activator X-43