Abstract: There is 1.08% copper，1.51% lead，and 2.36% zinc in a polymetallic Cu-Pb-Zn ore in Yunnan.For the development and utilization of the ore，experiment study on the ore was conducted.Results show that at grinding fine of 72.5% passing 0.075 mm，using zinc sulphate+EMT-12 as depressor，EMS-602 as collector via one roughing-three cleaning-one scavenging copper flotation，copper flotation tailing using lime as regulator，zinc sulfate+EMT-12 as depressor，EMS-001 as collector via one roughing-three cleaning-one scavenging lead flotation，lead flotation tailing using copper sulfate as activator，butyl xanthate+ethyl xanthate as collector via one roughing-three cleaning-one scavenging zinc flotation，zinc flotation tailing using EMH104+copper sulfate as activator，butyl xanthate as collector via one roughing-one scavenging sulfur flotation，copper concentrate with copper grade of 20.33% and recovery of 86.29%，lead concentrate with lead grade of 55.68% and recovery of 84.35%，zinc concentrate with zinc grade of 46.83% and recovery of 86.97%，sulfur concentrate with sulfur grade of 38.96% and recovery of 71.92% were obtained.Comprehensive recovery of copper，lead，zinc，sulfur was realized.

Key words: Cu-Pb-Zn polymetallic ore, Preferential flotation, Comprehensive recovery